Thomas Upton Sisson (September 22, 1869 - September 26, 1923) was a U.S. Representative from Mississippi.
Born near McCool, Attala County, Mississippi, Sisson moved with his father to Choctaw County, Mississippi. He attended the common schools and the French Camp Academy, Mississippi. He was graduated from Southwestern Presbyterian University, Clarkesville, Tennessee, in 1889. Principal of Carthage High School in 1889 and 1890 and of the graded schools of Kosciusko, Mississippi from 1890 to 1892. He studied law at the University of Mississippi at Oxford and was graduated from Cumberland School of Law at Cumberland University, Lebanon, Tennessee. He was admitted to the bar at Memphis, Tennessee, in 1894 and commenced practice in Winona, Mississippi. He served as member of the State senate in 1898. He served as district attorney of the fifth judicial district 1903-1907.
Sisson was elected as a Democrat to the Sixty-first and to the six succeeding Congresses (March 4, 1909-March 3, 1923). He was an unsuccessful candidate for reelection in 1922 to the Sixty-eighth Congress. He died in Washington, D.C., September 26, 1923. He was interred in Oak Hill Cemetery, Winona, Mississippi.